P-421 Return rates and outcome of fertility preservation in women with cervical cancer.

Abstract Study question What are the return rates and reproductive outcome after fertility preservation (FP) in women with cervical cancer (CC)? Summary answer Return FP CC seem to be comparable those for other indications. is known already Cervical fourth most common among women. Approximately 42% of affected under age 45, many them wish preserve at time diagnosis. Fertility sparing treatment modalities cryopreservation oocytes, embryos or/and ovarian tissue can offered this purpose carefully selected patients. These treatments Swedish academic centers within health insurance coverage available all citizens. To date, data on rates, survival undergoing scarce. design, size, duration Prospective, single center study aiming report long-term outcomes who have versus not undergone Karolinska University Hospital between January 1st 1999 September 30th 2018. Participants/materials, setting, methods During period, 74 received counseling Hospital, 52 proceeded FP. Data overall were extracted using clinical registries. Main results role chance By 15th, 2023, 22 returned a new counselling or treatment, mean was 4 years (1-7 years). Among cryopreserved (n = 40), 17 been contact clinic wish, 3 had re-transplantation tissue, but none achieved oocyte retrieval yet. Additionally, one woman planned February awaiting decision. In two cases decision re-transplant based absence endometrial growth following attempts hormonal substitutive therapy. oocytes 5), 1 thawing no pregnancy has achieved. during follow-up, 2 transfer, got pregnant gave birth child. Of combination cryopreserved, re-transplantation. Eight died follow-up because recurrence their cancer, group without Limitations, reasons caution This provides much needed real-world indicated by diagnosis CC, it limitations related its descriptive character. The use gestational carriers permitted Sweden program may differ from countries. Wider implications findings provide oncologic CC. Trial registration number NTC04602962